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People
Name:
 Huayu Tian
Education:
 Ph. D
Positions:
  
Academic title:
 professor
Postal Code:
 130022
Subject categories:
 Polymer
Mailing Address:
 Renmin Sreet 5625,Changchun city,Jilin province
E-mail:
 thy@ciac.ac.cn
Resume:
 Huayu Tian, Professor, Ph. D State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China Personal Data Date of birth: Jan. 20, 1977 Gender: Male Education 1994-1998 B.S, Polymer Science, Harbin Institute of Technology, China 1998-2000 M.S, Polymer Science, Harbin Institute of Technology, China 2002-2005 Ph.D, Polymer Science, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China Career 2008-Present Associate Professor, Biomedical Polymer Group, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China Aug. 2008 Visiting Researcher, Kyushu University, Japan (Professor Atsushi Maruyama's Lab) June-July 2007 Visiting Researcher, Korea Advanced Institute of Science and Technology, South Korea (Professor Tae Gwan Park's Lab) 2006-2008 Assistant Professor, Biomedical Polymer Group, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China
Direction:
 Polymer noviral gene carriers, drug carriers
Achievements:
Article:

[1]Liu, F.; Lin, L.; Zhang, Y.; Wang, Y.; Sheng, S.; Xu, C.; Tian, H.*; Chen, X.*, A Tumor-Microenvironment-Activated Nanozyme-Mediated Theranostic Nanoreactor for Imaging-Guided Combined Tumor Therapy, Advanced Materials, 2019, 31, 1902885.

[2]Liu, F.; Lin, L.; Zhang, Y.; Sheng, S.; Wang, Y.; Xu, C.; Tian, H.*; Chen, X., Two-dimensional nanosheets with high curcumin loading content for multimodal imaging-guided combined chemo-photothermal therapy, Biomaterials, 2019, 223, 119470.

[3]Wang, D.; Zhang, Z.; Lin, L.; Liu, F.; Wang, Y.; Guo, Z.; Li, Y.; Tian, H.*; Chen, X., Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy, Biomaterials, 2019, 223, 119459.

[4]Zhang, Y.; Lin, L.; Liu, L.; Liu, F.; Sheng, S.; Tian, H.*; Chen, X., Positive feedback nanoamplifier responded to tumor microenvironments for self-enhanced tumor imaging and therapy. Biomaterials, 2019, 216, 119255.

[5]Wang, K.; Zhang, Z.; Lin, L.; Chen, J.; Hao, K.; Tian, H.*; Chen, X., Covalent organic nanosheets integrated heterojunction with two strategies to overcome hypoxic-tumor photodynamic therapy. Chemistry of Materials, 2019, 31 (9), 3313-3323.

[6]Wang, Y.; Wang, Z.; Xu, C.*; Tian, H.*; Chen, X., A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy. Biomaterials, 2019, 197, 284-293.

[7]Fang, H.; Guo, Z.; Lin, L.; Chen, J.; Sun, P.; Wu, J.; Xu, C.; Tian, H.*; Chen, X.*, Molecular strings significantly improved the gene transfection efficiency of polycations. Journal of the American Chemical Society, 2018, 140 (38), 11992-12000.

[8]Zhen, W.; Liu, Y.; Lin, L.; Bai, J.; Jia, X.; Tian, H.*; Jiang, X.*, BSA-IrO2: catalase-like nanoparticles with high photothermal conversion efficiency and a high X-ray absorption coefficient for anti-inflammation and antitumor theranostics. Angewandte Chemie International Edition, 2018, 57 (32), 10309-10313.

[9]Xu, C.; Wang, Y.; Yu, H.; Tian, H.*; Chen, X.*, Multifunctional theranostic nanoparticles derived from fruit-extracted anthocyanins with dynamic disassembly and elimination abilities. ACS Nano, 2018, 12 (8), 8255-8265.

[10]Yan, N.; Wang, X.; Lin, L.; Song, T.; Sun, P.; Tian, H.*; Liang, H.*; Chen, X.*, Gold nanorods electrostatically binding nucleic acid probe for in vivo microRNA amplified detection and photoacoustic imaging-guided photothermal therapy. Advanced Functional Materials, 2018, 28 (22), 1800490.

[11]Guan, X.; Chen, J.; Hu, Y.; Lin, L.; Sun, P.; Tian, H.*; Chen, X., Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase. Biomaterials, 2018, 171, 198-206.

[12]Guan, X.; Guo, Z.; Lin, L.; Chen, J.; Tian, H.*; Chen, X.*, Ultrasensitive pH triggered charge/size dual-rebound gene delivery system. Nano Letters, 2016, 16 (11), 6823-6831.

[13]Xu, C.; Wang, P.; Zhang, J.; Tian, H.*; Park, K.; Chen, X.*, Pulmonary codelivery of doxorubicin and siRNA by pH-sensitive nanoparticles for therapy of metastatic lung cancer. Small, 2015, 11 (34), 4321-4333.
Community service:
Commitment to research the situation:

1、国家自然科学基金面上项目，51873208，聚氨基酸纳米载体在肿瘤免疫治疗中的应用研究，2019/01-2022/12，65万元，在研，主持

2、吉林省科技发展计划项目，20180414027GH，用于肥胖治疗的基因载体的构建与研究，2018/01-2020/12，25万元，在研，主持

3、吉林省重点科技攻关项目，20160204032GX，具有诊疗功能的基因载体的构建与产品开发，2016/01-2018/12，50万元，在研，主持

4、国家自然科学基金面上项目，21474104，用于间充质干细胞的高分子基因载体的设计制备和抗肿瘤治疗研究，2015/01-2018/12，88万元，在研，主持

5、中组部“万人计划”青年拔尖人才，2014年，240万元

6、国家自然科学基金优秀青年基金，51222307，高分子基因载体，2013/01-2015/12，100万元，已结题，主持

7、吉林省科技发展计划中青年科技创新领军人才及团队项目，20130521011JH，2013/01-20105/12，20万，已结题，主持

8 、吉林省科技发展计划重点项目，20120306，高分子基因载体的构建及肿瘤基因治疗研究，2012/07-2014/12，28万元，已结题，主持

9、中国科学院青年创新促进会, 2012/01-2015/12，40万

10、国家自然科学基金面上项目，21074129，具有荧光和胞内控制释放性能的非病毒基因载体，2011/01-2013/12，36万，已结题，主持

11、国家自然科学基金面上项目，50873102，具有细胞识别和胞内裂解功能的高分子基因载体体系的研究，2009/01-2011/12，35万，已结题，主持

12、国家自然科学基金面上项目（青年基金项目），20604028，靶向性非病毒基因载体改性聚乙烯亚胺的制备及研究，2007/01-2009/12，25万，已结题，主持